Lateral habenula as a source of negative reward signals in dopamine neurons

By Masayuki Matsumoto, Okihide Hikosaka. Nature, 2007

1,273 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/5e50e053887c7351550f0e4d6a65691f5162a293

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Wolfram Schultz
2. Yael Niv
3. Peter S. Dayan
4. Xiao-Jing Wang
5. Ann M. Graybiel
6. Okihide Hikosaka
7. Kenji Doya
8. Anthony A. Grace

In Cognitive Neuroscience

1. Wolfram Schultz
2. Peter S. Dayan
3. Yael Niv
4. Nathaniel D. Daw
5. Karl J. Friston
6. Michael J Frank
7. Xiao-Jing Wang
8. Gianluca Baldassarre

In Molecular Biology

1. Wolfram Schultz
2. Yael Niv
3. Anthony A. Grace
4. Okihide Hikosaka
5. Ann M. Graybiel
6. Peter S. Dayan
7. S. Sesack
8. Xiao-Jing Wang

Citations in the corpus

• Modulators of decision making (2008, background): “On the other hand, a recent recording study has clearly demonstrated that neurons in the lateral habenula respond to no-reward predictive cues as well as reward omission, in exactly the opposite way as dopamine neurons, and that stimulation of the lateral habenula causes inhibition of dopamine neuro”
• The rostromedial tegmental nucleus (RMTg), a GABAergic afferent to midbrain dopamine neurons, encodes aversive stimuli and inhibits motor responses. (2009, methodology): “We next examined the temporal characteristics of RMTg responses to appetitive and aversive stimuli, in order to determine whether they resemble responses previously observed in the lateral habenula (Matsumoto and Hikosaka, 2007).”
• The Reward Circuit: Linking Primate Anatomy and Human Imaging (2010, background): “Parts of the VP (along with the dorsal pallidum) project to the LHb, a structure now considered to be part of the reward circuit (Matsumoto and Hikosaka, 2007; Morissette and Boye, 2008; Ullsperger and von Cramon, 2003); Haber et al , 1993 #554; Parent, 1981 #12010 (see section below for a…”
• Dopamine in motivational control: rewarding, aversive, and alerting (2010, background): “Motivational value-coding DA neurons are located predominantly in the ventromedial SNc and throughout the VTA.”
• Decision making in recurrent neuronal circuits. (2008, background): “…reward-prediction errors with an opposite sign from dopamine neurons (exhibiting a strong increase in spiking activity when the actual reward is smaller than the expected outcome), suggesting that the lateral habenula is a source for negative prediction error signal (Matsumoto and Hikosaka, 2007).”