Perinatal exposure to low doses of bisphenol A affects body weight, patterns of estrous cyclicity, and plasma LH levels.

By B. Rubin, Mary K. Murray, D. Damassa, J. C. King, Ana M. Soto. Environmental Health Perspectives, 2001

650 citations recorded by the source corpus.

The nonsteroidal estrogenic compound bisphenol A (BPA) is a monomer used in the manufacture of polycarbonate plastics and resins. BPA may be ingested by humans as it reportedly leaches from the lining of tin cans into foods, from dental sealants into saliva, and from polycarbonate bottles into their contents. Because BPA is weakly estrogenic--approximately 10,000-fold less potent than 17beta-estradiol--current environmental exposure levels have been considered orders of magnitude below the dose required for adverse effects on health. Herein we demonstrate measurable effects on the offspring of Sprague-Dawley female rats that were exposed, via their drinking water, to approximately 0.1 mg BPA/kg body weight (bw)/day (low dose) or 1.2 mg BPA/kg bw/day (high dose) from day 6 of pregnancy through the period of lactation. Offspring exposed to BPA exhibited an increase in body weight that was apparent soon after birth and continued into adulthood. In addition, female offspring exposed perinatally to the high dose of BPA exhibited altered patterns of estrous cyclicity and decreased levels of plasma luteinizing hormone (LH) in adulthood. Administration of neither the doses of BPA that caused effects during perinatal exposure nor a 10-fold higher dose was able to evoke a uterotropic response in ovariectomized postpubertal females. These data indicate an increased sensitivity to BPA during the perinatal period and suggest the need for careful evaluation of the current levels of exposure to this compound.

Subfields: Health, Toxicology and Mutagenesis

View Paper: https://www.semanticscholar.org/paper/5e4739b606ed4d373ee13e4db8b43124a99334d5

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Health, Toxicology and Mutagenesis

1. F. V. vom Saal
2. J. Heindel
3. B. Rubin
4. Laura N. Vandenberg
5. J. Rochester
6. W. Welshons

Citations in the corpus

• Components of plastic: experimental studies in animals and relevance for human health (2009, background): “For example, there is an obesity epidemic in many regions of the world, and developmental exposure to BPA increases body weight later in life (Howdeshell et al. 1999; Takai et al. 2000; Rubin et al. 2001).”
• Metabolism Disrupting Chemicals and Metabolic Disorders (2016, positive): “receipts has been shown to increase weight gain and body fat after developmental exposure in rats [327-329] and mice [321, 330-332].”
• In vivo effects of bisphenol A in laboratory rodent studies. (2007, background): “[37] Rubin BS, Murray MK, Bamassa DA, King JC, Soto AM.”
• An Extensive New Literature Concerning Low-Dose Effects of Bisphenol A Shows the Need for a New Risk Assessment (2005, background): “A decrease in daily sperm production and fertility in males was also reported at doses between 0.2 and 20 µg/kg/day due to developmental or adult exposure (Al-Hiyasat et al. 2002; Chitra et al. 2003; Sakaue et al. 2001; vom Saal et al. 1998).”
• Endocrine disruptors and reproductive health: the case of bisphenol-A. (2006, background): “Laboratory rodents exposed perinatally to BPA had lower plasma LH concentrations than control animals after long-term ovariectomy ( Rubin et al., 2001 ).”