Power2: The power of yeast genetics applied to the powerhouse of the cell
By Jared Rutter, Adam L. Hughes. Trends in endocrinology and metabolism, 2015
800 citations recorded by the source corpus.
The budding yeast Saccharomyces cerevisiae has served as a remarkable model organism for numerous seminal discoveries in biology. This paradigm extends to the mitochondria, a central hub for cellular metabolism, where studies in yeast have helped reinvigorate the field and launch an exciting new era in mitochondrial biology. Here, we discuss few recent examples in which yeast research has laid a foundation for our understanding of evolutionarily conserved mitochondrial processes and functions; from the key factors and pathways involved in the assembly of the OXPHOS complexes, to metabolite transport, lipid metabolism, and interorganelle communication. We also highlight new areas of yeast mitochondrial biology that will likely aid in our understanding of mitochondrial etiology of disease in the years to come.
Subfields: Cellular and Molecular Neuroscience, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/5e3b3fc2e048af988e49c2fb176ce3a29f854a46
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In Molecular Biology
Citations in the corpus
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