Notch regulation of lymphocyte development and function

By Freddy Radtke, Anne Wilson, Stéphane J. C. Mancini, H. Macdonald. Nature Immunology, 2004

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Bone-marrow haematopoietic-stem-cell niches (2006, background): “Moreover, several Notch receptors and Notch-receptor ligands are expressed in the bone marro”
Visualization of the earliest steps of γδ T cell development in the adult thymus (2006, background): “, it is plausible that Notch is involved in the induction of Tcrd transcript”
Human Plasmacytoid Dendritic Cells Activated by CpG Oligodeoxynucleotides Induce the Generation of CD4+CD25+ Regulatory T Cells1 (2004, background): “There is a possibility that although CpG ODN-treated PDCs up-regulate costimulatory molecules, there may be a concomitant up-regulation of suppressive surface molecules such as Ig-like transcripts 3 and 4 (51, 52) and Notch receptor ligands (50, 53, 54) as well as down-regulation of surface markers ”
c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma. (2006, background): “Notch regulates c-myc in normal thymocytes In addition to its role in T-ALL, Notch1 is required for induction of T cell differentiation and subsequent nor- mal maturation of thymocytes (for review, see Radtke et al. 2004).”
Rbm15 Modulates Notch-Induced Transcriptional Activation and Affects Myeloid Differentiation (2007, background): “Notch receptors and ligands are widely expressed in the hematopoietic system, including hematopoietic stem cells, as well as in the lymphoid, myeloid, and erythroid lineages (8, 24, 41).”