Agonistic Properties of Cannabidiol at 5-HT1a Receptors

By E. Russo, Andrea Burnett, B. Hall, K. Parker. Neurochemical Research, 2005

810 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Pharmacology, Surgery

View Paper: https://www.semanticscholar.org/paper/5dd5020fbb932c90fc55ec5c81c832f2c31e6a83

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. E. Denovan‐Wright
2. M. Kelly
3. G. Guy
4. A. Bagher
5. Ethan B. Russo
6. R. Laprairie
7. V. Di Marzo

In Pharmacology

1. V. Di Marzo
2. G. Guy
3. Ethan B. Russo

In Surgery

1. G. Guy
2. Ethan B. Russo
3. V. Di Marzo

Citations in the corpus

• Cannabidiol Reduces the Anxiety Induced by Simulated Public Speaking in Treatment-Naïve Social Phobia Patients (2011, background): “The anxiolytic action of CBD may be mediated by 5-HT 1A receptors, as it displaces the agonist l3Hr8-OHDPAT from the cloned human 5-HT1A receptor in a concentration-dependent manner and exerts an effect as an agonist at the human 5-HT1A receptor in signal-transduction studies (”
• A tale of two cannabinoids: the therapeutic rationale for combining tetrahydrocannabinol and cannabidiol. (2006, positive): “Activity of CBD at that receptor has been independently confirmed [76], supporting a role in migraine and anxiety treatment.”
• Cannabidiol as a Potential Treatment for Anxiety Disorders (2015, background): “suggest CBD acts as a direct 5-HT1AR agonist [57], in vivo studies are more consistent with CBD acting as an allosteric modulator, or facilitator of 5-HT1A signaling [58].”
• Effects of cannabinoids and cannabinoid‐enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes (2011, background): “, 2006) and 5-HT (5-HT1A) (Russo et al., 2005; Campos and Guimarães, 2008; Resstel et al., 2009; Magen et al., 2010; Yang et al., 2010) receptors, CBD potentiates some therapeutic effects of THC (Varvel et al.”
• Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor (2015, background): “…(CBD) is known to modulate the activity of many cellular effectors, including CB1 and CB2 receptors (Hayakawa et al., 2008), 5HT1A receptors (Russo et al., 2005), GPR55 (Ryberg et al., 2007), the μ- and δ-opioid receptors (Kathmann et al., 2006), the TRPV1 cation channels (Bisogno et al.,…”