Genetics of autism: complex aetiology for a heterogeneous disorder.

By S. Folstein, B. Rosen-Sheidley. Nature reviews genetics, 2001

818 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/5dd20aa6997222d74c990b390e836b332a5a5222

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Citations in the corpus

Sociability and preference for social novelty in five inbred strains: an approach to assess autistic‐like behavior in mice (2004, methodology): “Most experimental groups consisted of male mice, for consistency with the 4:1 male:female difference in the diagnosis of autism (Folstein & Rosen-Sheidley 2001).”
A common genetic variant in the neurexin superfamily member CNTNAP2 increases familial risk of autism. (2008, unknown): “Compelling evidence for a genetic basis for autism has been provided by twin studies, demonstrating a significantly higher concordance rate for monozygous versus dizygous twins, with an overall heritability of 80%–90%.(3) Consequently, it is expected that appropriate genomic screens can identify sus”
Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism (2006, background): “Prevailing evidence supports the involvement of both genetic and environmental factors that interact to negatively affect prenatal and postnatal neurologic development [Folstein and Rosen-Sheidley, 2001; Keller and Persico, 2003].”
Behavioral Alterations in Rats Prenatally Exposed to Valproic Acid: Animal Model of Autism (2005, background): “The etiology of autism is not known but it has a strong genetic component (Folstein and Piven, 1991; Bailey et al, 1995; Folstein and Rosen-Sheidley, 2001), and an exposure to at least three teratogens appears to be a risk factor for the disorder: thalidomide (Strömland et al, 1994), valproic acid…”
Model of autism: increased ratio of excitation/inhibition in key neural systems (2003, background): “Twin studies have shown that autism is a strongly inherited disorder (Folstein & Rosen-Sheidley 2001; Rutter 2000; Veenstra-Vanderweele et al. 2003), as monozygotic twins co–inherit this syndrome several times more frequently than do dizygotics.”