Systematic review of microsatellite instability and colorectal cancer prognosis.

By S. Popat, R. Hubner, Richard S. Houlston. Journal of Clinical Oncology, 2005

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Immune infiltration in human tumors: a prognostic factor that should not be ignored (2010, background): “It is striking that MSI correlates with good prognosis (Popat et al., 2005), and an attractive hypothesis is that this is due to mismatch repair deficiency creating multiple immunogenic peptides that become stimulants and targets of antitumor immune responses (Schwitalle et al., 2008).”
Microsatellite instability in colorectal cancer—the stable evidence (2010, methodology): “A meta-analysis assessed individual clinical data from 32 studies that included 7,642 CRC cases, where 1,277 of these cases displayed MSI”
Impact of BRAF Mutation and Microsatellite Instability on the Pattern of Metastatic Spread and Prognosis in Metastatic Colorectal Cancer (2011, background): “In early stage CRC, MSI is a good prognostic factor, associated with significantly better survival than MSS tumors.(12) Multiple reports have also demonstrated that it is predictive for nonresponse to 5-fluorouracil chemotherapy in stage B disease.”
CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer (2008, result): “Consistent with other studies,[20] we found that MSI-high tumors showed a trend towards an association with longer survival.”