Cytochrome c release and apoptosis induced by mitochondrial targeting of nuclear orphan receptor TR3.
By H. Li, S. Kolluri, J. Gu, M. Dawson, X. Cao, P. Hobbs, B. Lin, G. Chen, J. Lu, F. Lin and 4 more. Science, 2000
679 citations recorded by the source corpus.
Subfields: Cellular and Molecular Neuroscience, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/5d6d745ef947abcf0d888a5fb81721286b7662eb
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In Molecular Biology
- Jill P. Mesirov
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- X. Wang
- Yujin Hoshida
- Haesun Park
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Citations in the corpus
- Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning (2002, background): “Recent studies indicate that at least one NGF1B family member (NGF1B/TR3/Nur77) translocates from the nucleus to the mitochondria where it directly exerts its proapoptotic effect”
- Viruses and apoptosis (2001, background): “Interestingly, a growing number of apoptotic messengers, including transcription factors (Li et al. 2000) and p53 (Marchenko et al. 2000), have now been shown to share the capacity to translocate to the mitochondrial membrane, although the mechanisms by which this occurs are not clear.”
- The expanding role of mitochondria in apoptosis. (2001, background): “Cells from the cytochrome-c-deficient mouse embryos that survived up to embryonic day 8.5 showed a similar deficiency in response to various apoptotic stimuli (Li et al. 2000).”
- The transcription factor NR4A1 (Nur77) controls bone marrow differentiation and survival of Ly6C− monocytes (2011, neutral): “In response to apoptotic stimuli, NR4A1 may form a dimer with retinoid X receptor and translocate from the nucleus to the cytoplasm, where it can target mitochondria to induce the release of cytochrome c and apoptosi”
- Apoptosis-based therapies (2002, background): “Certain apoptotic stimuli induce the translocation of NUR77 from the nucleus to the surface of mitochondria, where it triggers cytochrome c release and apoptosis through an undefined mechanis”
- Cyclooxygenase‐independent actions of cyclooxygenase inhibitors (2001, neutral): “duce cytochrome c release and apoptosis (201).”