Role of T Lymphocytes and Interferon-γ in Ischemic Stroke

By Gokhan Yilmaz, T. Arumugam, K. Stokes, D. Granger. 2006

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Ischemia and reperfusion—from mechanism to translation (2011, background): “Studies of mouse lines deficient in specific populations of lymphocytes showed that both CD4 + and CD8 + T cells have a detrimental role in ischemia and reperfusion of the brai”
Inflammatory mechanisms in ischemic stroke: role of inflammatory cells (2010, background): “In contrast to the rapid resident microglia response, blood-derived leukocytes are recruited to the brain tissue, usually with a delay of hours to a few days [24, 25, 40].”
The immunology of stroke: from mechanisms to translation (2011, background): “It is also surprising that, unlike autoimmune responses in other organs where there is a prevalence for either T helper or T effector cell participation, both CD4 + and CD8 + T cells are involved in ischemic injur”
Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke (2009, background): “Proinflammatory cytokine antagonization reduces brain damage Proinflammatory mediators such as TNF-α and IFN-γ contribute to the detrimental postischemic brain inflammatio”
Microbiota Dysbiosis Controls the Neuroinflammatory Response after Stroke (2016, methodology): “Experimental approaches using pharmacological or genetic lymphocyte depletion paradigms (Yilmaz et al., 2006; Kleinschnitz et al., 2010) or pharmaReceived April 4, 2016; revised May 6, 2016; accepted May 31, 2016.”