Glycan Shield and Fusion Activation of a Deltacoronavirus Spike Glycoprotein Fine-Tuned for Enteric Infections

By X. Xiong, M. A. Tortorici, Joost Snijder, C. Yoshioka, C. Alexandra, Walls, Wentao Li, Andrew T. McGuire, F. Rey, B. Bosch and 2 more. 2017

161 citations recorded by the source corpus.

Subfields: Animal Science and Zoology, Genetics, Infectious Diseases

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Animal Science and Zoology

1. D. Veesler
2. A. Walls
3. M. A. Tortorici
4. A. Tortoricia
5. David Veeslera
6. L. Enjuanes

In Genetics

1. M. A. Tortorici
2. Frank G. Grosveld
3. Andrew T. McGuire
4. Young-Jun Park
5. A. Walls
6. D. Veesler

In Infectious Diseases

1. D. Veesler
2. A. Walls
3. M. A. Tortorici
4. A. Tortoricia
5. David Veeslera
6. Andrew T. McGuire
7. A. Wall
8. Young-Jun Park

Citations in the corpus

• Unexpected Receptor Functional Mimicry Elucidates Activation of Coronavirus Fusion (2020, unknown): “S is composed of two functional subunits responsible for binding to the host cell receptor (S1 subunit) and fusion of the viral and cellular membranes (S2 subunit) (Gui et al., 2017; Kirchdoerfer et al., 2016; Pallesen et al., 2017; Shang et al., 2017, 2018; Walls et al., 2016a, 2016b, 2017; Xiong e”
• Structural insights into coronavirus entry (2019, background): “In the context of the S trimer, β/γ CoV B domains interact with the A and B domains of another protomer, whereas they pack against the A domain of the same protomer in α/δ-CoVs (Shang et al., 2018a; Walls et al., 2016a, b; Xiong et al., 2018).”
• Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of Antibodies (2020, unknown): “Hower, structures of S trimer, RBD-Fab, RBD-ACE2, and S mer-Fab complexes for SARS-CoV-2 and other coronaviruses e informative for interpreting and understanding the antibody sponse to SARS-CoV-2 (Gui et al., 2017; Kirchdoerfer et al., 16, 2018, 2020; Pallesen et al., 2017; Pinto et al., 2020; Shang”
• Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein (2020, background): “We previously showed that coronavirus S glycoproteins are densely decorated by heterogeneous N-linked glycans protruding from the trimer surface (Walls et al., 2016b; Walls et al., 2019; Xiong et al., 2018).”
• Towards a solution to MERS: protective human monoclonal antibodies targeting different domains and functions of the MERS-coronavirus spike glycoprotein (2019, background): “Single-particle cryo-electron microscopic analyses of trimeric S ectodomains of several coronaviruses, including MERS-CoV [7] [8] [9] [10] [11] [12] [13] , revealed a multi-domain architecture of the S1 subunit, consisting of four core domains (designated A though D).”