The viral polymerase mediates adaptation of an avian influenza virus to a mammalian host.

By G. Gabriel, Bianca Dauber, T. Wolff, O. Planz, H. Klenk, J. Stech. Proceedings of the National Academy of Sciences of the United States of America, 2005

711 citations recorded by the source corpus.

Subfields: Agronomy and Crop Science, Epidemiology, Infectious Diseases

View Paper: https://www.semanticscholar.org/paper/5cf5c7f966a4936309c7f679988151acea2257b5

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Agronomy and Crop Science

1. J. Taubenberger
2. Ian A. Wilson
3. J. Kash
4. A. Varki
5. Raymond Tellier

In Epidemiology

1. J. Taubenberger
2. A. García‐Sastre
3. P. Palese
4. J. Steel
5. Anice C. Lowen
6. J. Kash
7. R. Medina
8. S. Mubareka

In Infectious Diseases

1. P. Palese
2. Ian A. Wilson
3. J. Taubenberger
4. J. Kash
5. Edward C. Holmes

Citations in the corpus

• Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia (2006, background): “Notably, three of four viruses without this substitution, but none of the viruses containing Lys627, contained an D701N substitution in PB2 that has been associated with adaptation of H7N7 viruses to mammalian cell”
• Avian Influenza Virus (H5N1): a Threat to Human Health (2007, background): “The importance of the polymerase complex in the adaptation to new hosts is being increasingly recognized and is discussed further below (55, 184).”
• New World Bats Harbor Diverse Influenza A Viruses (2013, background): “However, previous reports have shown that differences of this magnitude could be determined by a single amino-acid substitution in one of the polymerase proteins [11,12].”
• Transmission of Influenza Virus in a Mammalian Host Is Increased by PB2 Amino Acids 627K or 627E/701N (2009, background): “Similarly to E627K, a change of PB2 amino acid 701 from aspartic acid to asparagine has been implicated in expanding the host range of avian (or avian-like) H5N1 and H7N7 subtype viruses to include mice [19,20] and humans [1].”
• Influenza A viruses: new research developments (2011, background): “A D701N mutation in PB2 has also been implicated in the adaptation of AIVs to growth in mammalian cell”
• Influenza Virus Evolution, Host Adaptation and Pandemic Formation (2010, background): “, 2007), have similarly been identified as a host-adaptive locus (Gabriel et al., 2005), with the D701N mutation increasing both replication in mice (Li et al.”