Reactive oxygen species and superoxide dismutases: role in joint diseases.

By Valéry Afonso, R. Champy, D. Mitrovic, P. Collin, A. Lomri. Joint, bone, spine : revue du rhumatisme, 2007

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Role of proinflammatory cytokines in the pathophysiology of osteoarthritis (2011, background): “IL-1β and TNF also induce the production of reactive oxygen species (ROS)—mainly NO and the superoxide anion—that generate hydrogen peroxide, peroxynitrite and hydroxyl radicals”
The Role of Inflammatory and Anti-Inflammatory Cytokines in the Pathogenesis of Osteoarthritis (2014, background): “During the course of the disease, IL-1β stimulates the production of reactive oxygen species (ROS), which generate the formation of, for example, peroxides and hydroxylated radicals, which directly damage the articular cartilage; the intensification of this process is also associated with decreased ”
Cellular Stress Responses, The Hormesis Paradigm, and Vitagenes: Novel Targets for Therapeutic Intervention in Neurodegenerative Disorders (2010, neutral): “The damaging effects of excessive production of ROS are believed to contribute to a wide range of diseases, including cancers, cardiovascular disease, and inﬂammatory conditions such as arthritis (2, 250, 296).”