Role of proinflammatory cytokines in the pathophysiology of osteoarthritis

By M. Kapoor, J. Martel-Pelletier, D. Lajeunesse, J. Pelletier, H. Fahmi. Nature Reviews Rheumatology, 2011

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How researchers see this paper

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Cytokines in Sepsis: Potent Immunoregulators and Potential Therapeutic Targets—An Updated View (2013, background): “Both are powerful proinflammatory cytokines that have been implicated in a large number of infectious and noninfectious inflammatory diseases, the latter including atherosclerosis [35], rheumatoid arthritis [36], osteoarthritis [105], and Alzheimer’s disease [38].”
The Role of Synovitis in Osteoarthritis pathogenesis (2012, background): “These mediators may be produced by a variety of cell types, including macrophages, chondrocytes and synovial fibroblasts [51].”
Osteoarthritis: pathogenic signaling pathways and therapeutic targets (2023, background): “Additionally, numerous NFκB-mediated cytokines and chemokines, including receptor activators (RANKL) of TNF-α, IL-1β, IL-6, and NF-κB (RANK) ligands expressed in OA articular chondrocytes could upregulate MMP production, reduce the cellular synthesis of collagen and proteoglycan, and act in a positi”
Damage-Associated Molecular Patterns in Inflammatory Diseases (2018, background): “However, emerging evidence suggests that DAMPs-induced inflammation plays an important role in the pathogenesis of OA (14,52,53).”