Identification of genes that modify ataxin-1-induced neurodegeneration
By Pedro Fernandez-Funez, M. L. Nino-Rosales, B. Gouyon, Wei-Chi She, J. M. Luchak, P. Martinez, E. Turiégano, Jonathan Benito, M. Capovilla, P. Skinner and 5 more. Nature, 2000
684 citations recorded by the source corpus.
Subfields: Cellular and Molecular Neuroscience, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/5c593e0a395b159cca88f54935dae5ec287ff7b3
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In Cellular and Molecular Neuroscience
In Molecular Biology
- Albert-László Barabási
- Marc Vidal
- David E. Hill
- Leslie M. Thompson
- A. Kazantsev
- H. Zoghbi
- Jennifer L. Wacker
- P. Muchowski
Citations in the corpus
- Diseases of Unstable Repeat Expansion: Mechanisms and Common Principles (2005, background): “melanogaster model of SCA1 are proteins that are involved in RNA binding and processin”
- Therapeutic application of histone deacetylase inhibitors for central nervous system disorders (2008, background): “Moreover, an early genetic screen in a fly model of SCA1 revealed genetic modifiers within the context of chromatin remodellin”
- A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (2006, background): “…analysis data are consistent with previous genetic studies illustrating that many genetic modifiers belong to GO categories such as transcriptional regulation, RNA splicing, and protein degradation (Fernandez-Funez et al., 2000; Cummings et al., 2001; Zoghbi and Botas, 2002; Ghosh and Feany, 2004).”
- Modulation of neurodegeneration by molecular chaperones (2005, background): “In fruitfly and yeast screens several HSP40 homologues have been identified as potent suppressors of polyQ-mediated toxicit”
- RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia (2004, background): “Results in fruit fly models and transgenic mice show that the expansion confers a toxic gain of function on ataxin-1 (refs”
- The Fly as a Model for Neurodegenerative Diseases: Is It Worth the Jump? (2007, neutral): “investigated the Drosophila homologue dAtx2. The variety of fly phenotypes observed upon either a reduction or an increase in dAtx2 activity appeared to be the result of defective actin filament formation, thus indicating that Atx2 may have a role in regulating the cytoskeleton and possibly tran”