A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.

By Janghoo Lim, Tong Hao, Chad A. Shaw, Akash J. Patel, Gábor Szabó, Jean‐François Rual, C. Fisk, Ning Li, A. Smolyar, David E. Hill and 3 more. Cell, 2006

805 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/004c6f9ed1ba9618b71c1ae1af6cc1dd24270932

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Citations in the corpus

The Human Phenotype Ontology (2010, background): “The importance of diseasomics has become ever more obvious in the field of human genetics with the identification of biochemical or protein interaction networks whose dysfunction underlies groups of phenotypically related diseases (54, 55).”
The Fly as a Model for Neurodegenerative Diseases: Is It Worth the Jump? (2007, positive): “All the above studies point to several pathways involved in SCA1 pathogenesis and their modulation holds therapeutic value. Interestingly, a recent landmark paper that established an interaction network for proteins involved in inherited ataxias using a stringent yeast 2-hybrid screen confirmed many”
Visualization of genetic disease-phenotype similarities by multiple maps t-SNE with Laplacian regularization (2014, background): “Background A large number of studies proved that mutations of functionally related genes are associated with genetic diseases characterized with overlapping phenotypes [1,2].”
Network-based global inference of human disease genes (2008, background): “…al , 2007; Wood et al , 2007), suggests that causative genes for the same or phenotypically similar diseases may generally reside in the same biological module, either a protein complex (Lage et al , 2007), a pathway (Wood et al , 2007), or a subnetwork of protein interactions (Lim et al , 2006).”
Structure and dynamics of molecular networks: A novel paradigm of drug discovery: A comprehensive review (2012, background): “…of poly-glutamine proteins (and their known interactome neighbors) Identification of novel modifiers of disease progression Goehler et al., 2004; Lim et al., 2006; Kaltenbach et al., 2007; Kahle et al., 2011 Prion disease Differentially co-expressed gene networks of normal and prion disease…”
Network analyses in systems pharmacology (2009, background): “These include asthma, schizophrenia, cardiovascular disease, various cancers and various infectious diseases (Camargo et al., 2007; Chu and Chen, 2008; Durmus et al., 2009; Fatumo et al., 2009; Hwang et al., 2008a; Hyduke et al., 2007; Lim et al., 2006; Raman and Chandra, 2008; Tanaka et al., 2008).”
Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders (2015, methodology): “Lim and colleagues 164 used a seed-based approach based on a Y2H screen to identify interactors of the protein products of multiple causal and candidate genes in inherited ataxias.”
HIPPIE: Integrating Protein Interaction Networks with Experiment Based Quality Scores (2012, methodology): “Additionally, we integrated interactions from manually selected studies [12,13,14,15,16,17,18,19,20,21,22]; interactions from these studies were integrated that were not contained in the public databases at the time of integrating the sources.”
Chapter 4: Protein Interactions and Disease (2012, background): “(vi) Etiologically unrelated diseases often present similar symptoms because separate biological processes often use common molecular pathways [75].”
Yeast Two-Hybrid, a Powerful Tool for Systems Biology (2009, positive): “Experimental Y2H data have been a crucial part in establishing large synthetic human interactomes [25,26] or to dissect mechanisms in human disease [27].”
Network-based methods for human disease gene prediction. (2011, background): “Lim et al. [53] and Kahle et al. [54] used Medicare patient records to determine if any disease associated with proteins in the ataxia interactome also co-occurs with hereditary ataxia.”
Protein networks in disease. (2008, background): “information ( Letovsky and Kasif 2003; Vazquez et al. 2003; Espadaler et al. 2005; Leone and Pagnani 2005; Bandyopadhyay et al. 2006; Lee et al. 2006).”
GATES: a rapid and powerful gene-based association test using extended Simes procedure. (2011, background): “A module can be a protein complex,(47) a pathway,(48) or a subnetwork of PPIs.(49)Within amodule, unknown underlying disease-susceptibility genes could be predicted on the basis of some known ones.”