Original antigenic sin and apoptosis in the pathogenesis of dengue hemorrhagic fever

By J. Mongkolsapaya, W. Dejnirattisai, Xiao-ning Xu, Sirijitt Vasanawathana, N. Tangthawornchaikul, Aroonrung Chairunsri, Siraporn Sawasdivorn, Thaneeya Duangchinda, T. Dong, S. Rowland-Jones and 4 more. Nature Medicine, 2003

851 citations recorded by the source corpus.

Subfields: Infectious Diseases, Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/5c29334c20123e4cd9a70444b00cfea48c8ea580

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Infectious Diseases

1. Alessandro Sette
2. E. Harris
3. J. Kyle

In Public Health, Environmental and Occupational Health

1. E. Harris
2. J. Kyle

Citations in the corpus

• Immunity to dengue virus: a tale of original antigenic sin and tropical cytokine storms (2011, background): “Given that there is ∼70% amino acid identity between the four dengue virus serotypes, T cell epitopes are highly conserved across serotypes, with the typical epitope having >6 residues that are completely conserved and several others that are reasonably well conserve”
• Dengue and severe dengue (2025, neutral): “The hyperinflammatory states in patients with severe dengue could be further exacerbated by compromised cell-mediated immune functions against DENV infection (164, 165).”
• Global spread and persistence of dengue. (2008, background): “There is immunological evidence that this phenomenon of “original antigenic sin” may occur during secondary DENV infections (91).”
• Into the Eye of the Cytokine Storm (2012, neutral): “These and other data (102) suggest that T cells are potent contributors of cytokines to the inflammatory milieu in infected tissues and that this contributes to vasodilation during this critical phase of the illness, although not all studies have found evidence in support of this hypothesis (44).”
• Comprehensive analysis of dengue virus-specific responses supports an HLA-linked protective role for CD8+ T cells (2013, background): “Another hypothesis postulates that T cells raised against the first infecting serotype dominate during a secondary heterologous infection in a phenomenon termed “original antigenic sin” (16, 17).”
• Dengue: a continuing global threat (2010, background): “…CD4 + and CD8 + cells that have a diminished capacity to kill but nonetheless release inflammatory cytokines that contribute to disease severity 51 ; that severe disease is caused by DENVs of increased virulence 52 ; and the suggestion that cross-reactivity between NS1 and human platelets and…”