Classification of primary progressive aphasia and its variants

By Maria Luisa Gorno-Tempini, A. Hillis, S. Weintraub, A. Kertesz, Mario F. Mendez, S. Cappa, J. Ogar, Jonathan D. Rohrer, S. Black, Brad Boeve and 10 more. Neurology, 2011

4,362 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/5c1a1c74216e0e8e08271a6857752177e1f507ad

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Citations in the corpus

Criteria for the diagnosis of corticobasal degeneration (2013, background): “Reports most commonly categorized the aphasia as primary progressive aphasia (PPA), progressive aphasia, or progressive nonfluent aphasia (PNFA), though these terms overlap and reflect older terminology that has recently been revised.(35) Aphasic patients with CBD may progress to mutism.”
Clinical diagnosis of Alzheimer’s disease: recommendations of the International Working Group (2021, background): “phenotypes) are: the amnestic syndrome of the hippocampal type 66 (typical), the posterior cortical atrophy variant 67 , and the logopenic variant primary progressive aphasia 68,69 (Supplementary Figure 1).”
The neuropathological diagnosis of Alzheimer’s disease (2019, background): “Patients with primary progressive aphasias presenting as agrammatic, semantic or logopenic variants most commonly have frontotemporal lobar degeneration, but hippocampal sparing AD can also present in this manner [7, 102].”
The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease (2011, background): “For example, Dementia with Lewy bodies [8], vascular dementia [9], behavior variant frontotemporal dementia [10–12], and primary progressive aphasia [13] have been characterized extensively.”
TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis (2014, background): “(%) 113 (58)/81 (42) 55 (63)/33 (37) 38 (68)/18 (32) 20 (40)/30 (60) 0.”
Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer's disease. (2016, methodology): “…disease’; Crutch et al., 2012), logopenic variant primary progressive aphasia (logopenic variant PPA, ‘lan- guage variant of Alzheimer’s disease’; Gorno-Tempini et al., 2011), corticobasal syndrome (Alzheimer’s disease path- ology is the causative pathology in up to 25% of…”
Alzheimer's disease (2018, background): “In LPA, patients present with prominent word finding pauses, anomia and impairments in working memory [42].”
Clinical Neurology and Epidemiology of the Major Neurodegenerative Diseases. (2018, background): “…svPPA have impairment in confrontational naming (i.e., the ability to produce the word for an object after seeing it or its picture), single-word comprehension, and object knowledge (particularly for uncommon objects), with spared repetition and speech sound production (Gorno-Tempini et al. 2011).”
Identification of pre-clinical Alzheimer’s disease by a profile of pathogenic proteins in neurally-derived blood exosomes: a case-control study (2014, methodology): “Their diagnosis and assignment to mild dementia or moderate dementia groups (Table 1) was based on standard clinical, mental status, and psychiatric criteria, including discriminant analyses of neuropsychiatric elements, phonological performance, and object understanding that distinguish FTD from AD”