The origins, patterns and implications of human spontaneous mutation

By J. Crow. Nature reviews genetics, 2000

924 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/5bfbff90c1b43c36f3c3b40b41b2ce91fcd8d426

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Citations in the corpus

Maternal age affects offspring lifespan of the seed beetle, Callosobruchus maculatus (2003, background): “These extra cell divisions can translate into an increase in the risk of spontaneous mutations (Crow 1999; review in Crow 2000) which could affect offspring longevity.”
Rate, molecular spectrum, and consequences of human mutation (2010, background): “Dating back to Muller (49), considerable thought has been given to the potential for a cumulative buildup of the deleterious-mutation load in the human population (2, 3, 50, 51).”
Risk factors for autism: perinatal factors, parental psychiatric history, and socioeconomic status. (2005, background): “Genetic inheritance might be related to high parental age (39).”
A genome-wide view of the spectrum of spontaneous mutations in yeast (2008, background): “sapiens: mutation rate estimates (22, 54, 56–58); rates for homopolymeric runs assume an average 35 times inflation over that for microsatellites of the same size (the observed inflation in yeast); assumes 200 germ-line cell divisions per generation (3).”
Spontaneous Mutation Accumulation Studies in Evolutionary Genetics (2009, background): “This is important because synergistic epistasis could be a mechanism for limiting the load of mutations (Crow 2000), and it is a key feature in some models for the evolution of sexual reproduction (Kondrashov 1988).”
Whole Genome Sequencing in Autism Identifies Hotspots for De Novo Germline Mutation (2012, neutral): “In contrast to the SV hot spots described above that are predominantly driven by meiotic recombination, nucleotide substitution can occur by a variety of mechanisms, and the mutation rate is influenced to a much greater extent by mitotic mechanisms (Crow, 2000).”
Relaxed selection in the wild. (2009, background): “Research on suites of traits involving both morphology and behavior meet this expectation in stickleback [44], phrynosomatid lizards [ 45 ], village weaverbirds [42] and Spermophilus ground squirrels [22].”
The human Y chromosome: an evolutionary marker comes of age (2003, background): “Studies of genetic diseases show a strong bias towards fathers as the source of new mutations, and also show increasing mutation rate with paternal age (reviewed in Ref”
Patterns and rates of exonic de novo mutations in autism spectrum disorders (2012, result): “…result is that paternal and maternal age, themselves highly correlated (r 2 =0.679, P-value 0.0001), each strongly predicts the number of de novo events per offspring (paternal age P=0.0013, maternal age P=0.000365), consistent with aggregating mutations in germ cells in the paternal line 13 .”