Fine-scale recombination rate differences between sexes, populations and individuals

By A. Kong, G. Thorleifsson, Daniel Fannar Gudbjartsson, G. Másson, A. Sigurdsson, Á. Jónasdóttir, G. Bragi Walters, Adalbjorg Jonasdottir, A. Gylfason, Kari Kristinsson and 5 more. Nature, 2010

612 citations recorded by the source corpus.

Subfields: Genetics

View Paper: https://www.semanticscholar.org/paper/5bba89a84ae9fc5be60fad6211917d33dc9bc760

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In Genetics

Citations in the corpus

Fast and accurate long-range phasing in a UK Biobank cohort (2015, positive): “LRP has been successfully used in the Icelandic population to rapidly determine highly accurate phase and impute rare variants, producing insights into fine-scale recombination and enabling dozens of discoveries regarding numerous diseases [14–27].”
Major Histocompatibility Complex Genomics and Human Disease (2013, neutral): “In terms of the recombination landscape of the MHC, data are shown for the deCODE recombination map (69) (dark brown), representing calculated rates of recombination (sex-averaged) using 10-kb windows.”
A General Approach for Haplotype Phasing across the Full Spectrum of Relatedness (2014, methodology): “To reliably detect recombination events, a Lander-Green implementation requires either a nuclear family with at least three children or a three generation pedigree [39,40].”
A reference data set of 5.4 million phased human variants validated by genetic inheritance from sequencing a three-generation 17-member pedigree (2016, positive): “In agreement with previous studies (Kong et al. 2010), we observed a higher number of crossovers in maternal versus paternal autosomal haplotypes: 58% (415/709, 1.35 cM/Mb) compared to 42% (302/709, 0.98 cM/Mb) (Supplemental Fig.”
BCFtools/RoH: a hidden Markov model approach for detecting autozygosity from next-generation sequencing data (2016, background): “This is then multiplied by the probabilities for transitions between states, p NH and p HN .”