Helicobacter pylori Vacuolating Cytotoxin Inhibits T Lymphocyte Activation

By B. Gebert, W. Fischer, Evelyn Weiss, R. Hoffmann, R. Haas. Science, 2003

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Mechanisms of disease: Helicobacter pylori virulence factors (2010, background): “VacA can also specifically inhibit T-cell activation and proliferation”
Fusobacterium nucleatum and T-cells in Colorectal Carcinoma (2015, neutral): “0001 High 94 (16) 66 (13) 12 (33) 16 (42)”
Helicobacter pylori and Gastric Cancer: Factors That Modulate Disease Risk (2010, background): “pylori, which may contribute to the longevity of infection (35, 111, 299).”
Helicobacter pylori: gastric cancer and beyond (2010, background): “VacA binding to integrin β2 blocks antigen-dependent proliferation of transformed T cells by interfering with interleukin-2 ( IL-2 )-mediated signalling through the inhibition of Ca 2+ mobilization and downregulation of the Ca 2+ -dependent phosphatase calcineuri”
Anti-immunology: evasion of the host immune system by bacterial and viral pathogens. (2006, background): “activated T cells (NFAT), a global regulator of immune response genes (Gebert et al., 2003).”
Pathogenesis of Helicobacter pylori Infection (2006, background): “Purified VacA spontaneously forms oligomeric aggregates ( 900 kDa) and on M arch 30, 2021 by guest http://cm r.asm .org/ D ow nloaded from upon exposure to acidic pH disassembles into the active monomers that form pores in the cell membrane (104, 380, 436).”