Combining non-invasive transcranial brain stimulation with neuroimaging and electrophysiology: Current approaches and future perspectives

By Til Ole Bergmann, Anke N. Karabanov, Gesa Hartwigsen, Axel Thielscher, Hartwig Roman Siebner. NeuroImage, 2016

322 citations recorded by the source corpus.

Non-invasive transcranial brain stimulation (NTBS) techniques such as transcranial magnetic stimulation (TMS) and transcranial current stimulation (TCS) are important tools in human systems and cognitive neuroscience because they are able to reveal the relevance of certain brain structures or neuronal activity patterns for a given brain function. It is nowadays feasible to combine NTBS, either consecutively or concurrently, with a variety of neuroimaging and electrophysiological techniques. Here we discuss what kind of information can be gained from combined approaches, which often are technically demanding. We argue that the benefit from this combination is twofold. Firstly, neuroimaging and electrophysiology can inform subsequent NTBS, providing the required information to optimize where, when, and how to stimulate the brain. Information can be achieved both before and during the NTBS experiment, requiring consecutive and concurrent applications, respectively. Secondly, neuroimaging and electrophysiology can provide the readout for neural changes induced by NTBS. Again, using either concurrent or consecutive applications, both "online" NTBS effects immediately following the stimulation and "offline" NTBS effects outlasting plasticity-inducing NTBS protocols can be assessed. Finally, both strategies can be combined to close the loop between measuring and modulating brain activity by means of closed-loop brain state-dependent NTBS. In this paper, we will provide a conceptual framework, emphasizing principal strategies and highlighting promising future directions to exploit the benefits of combining NTBS with neuroimaging or electrophysiology.

Subfields: Cognitive Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/5ba367d2bfa3115fd2f26145a3d3f0033fb0eca1

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Citations in the corpus

Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS): An update (2014–2018) (2019, unknown): “Only subtle changes in transcallosal functional connectivity were evidenced after cTBS on high-density EEG.”
Analysing concurrent transcranial magnetic stimulation and electroencephalographic data: A review and introduction to the open‐source TESA software (2017, unknown): “…concurrent transcranial magnetic stimulation and electroencephalographic data: A review and introduction to the open-source TESA software Nigel C. Rogascha,⁎, Caley Sullivanb, Richard H. Thomsonb, Nathan S. Rosec, Neil W. Baileyb, Paul B. Fitzgeraldb, Faranak…”
The non-transcranial TMS-evoked potential is an inherent source of ambiguity in TMS-EEG studies (2018, background): “This is an open access a pathways which can then be captured with functional brain mapping techniques (Bergmann et al., 2016; Siebner et al., 2009).”
Tuning out emotional distractors by tuning in theta rhythm: improving visual working memory using transcranial magnetic stimulation (2026, unknown): “Different frequencies can be used to entrain specific EEG rhythms using rhythmic TMS (rhTMS) (Bergmann et al .”
Closing the loop between brain and electrical stimulation: towards precision neuromodulation treatments (2023, background): “Both online (concurrent effects) and of ﬂ ine (immediate aftereffects) protocols could be used to close the loop between the brain and stimulation parameters [68].”
Inferring Causality from Noninvasive Brain Stimulation in Cognitive Neuroscience (2020, methodology): “Yet, cortico-cortical spread has been demonstrated by combined NIBS–fMRI studies, which revealed strong remote effects of TMS in networks for various motor and cognitive functions (Bergmann et al., 2016; Bestmann & Feredoes, 2013).”