The N‐end rule pathway and regulation by proteolysis

By A. Varshavsky. Protein Science, 2011

682 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/5b182d2e1981c23fae1778e8e153654ec2021766

How researchers see this paper

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In Molecular Biology

1. G. Feng
2. R. Yasuda
3. L. Looger
4. Karel Svoboda

Citations in the corpus

• The world of protein acetylation. (2016, background): “Other recent studies demonstrate that Nt-acetylated N-termini may act as proteasomal degradation signals, decreasing protein half-life and being part of the N-end rule pathway [75,76].”
• Imaging Neural Activity Using Thy1-GCaMP Transgenic mice (2012, background): “0 to valine to increase its stability according to the N-terminal rule of protein degradation (Varshavsky, 2011) and changed the serine at 118 to cysteine as in GCaMP2.”
• High-throughput Analysis of in vivo Protein Stability* (2013, background): “This concept was also explored with physiological substrates (19, 20), which further expanded the functions of the N-end rule pathway (21, 22).”