Recruitment of IκBα to the hes1 promoter is associated with transcriptional repression

By Cristina Aguilera, Ruben Hoya-Arias, G. Haegeman, L. Espinosa, A. Bigas. 2004

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IκB Kinase α-Mediated Derepression of SMRT Potentiates Acetylation of RelA/p65 by p300 (2006, background): “Although I B has been proposed to downregulate NF- B and Notch-responsive gene targets through chromatin-mediated mechanisms (2, 14), the chromatin-associated I B protein did not correspond with SMRT-HDAC3-mediated repression in our model system.”
Integrating cell-signalling pathways with NF-κB and IKK function (2007, background): “For example, a nuclear role for IκBα as a promoter-bound transcriptional repressor of the Notch-target gene hes1 , which encodes a transcriptional repressor and regulator of cell differentiation, has been describe”