The Toll-Like Receptor 2 pathway Establishes Colonization by a Commensal of the Human Microbiota

By 박주홍, 김형표. 2011

746 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/5b077233839c61489b19ab7ad34261e1a0405341

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Citations in the corpus

Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis (2013, background): “…of the P. copri-dominated microbiome is a community shift away from Bacteroides, Group XIV Clostridia, Blautia, and Lachnospiraceae clades, previously reported to be associated with an anti-inflammatory state and regulatory T-cell (Treg) production (Atarashi et al., 2011; Round et al., 2011).”
Small Molecules from the Human Microbiota (2015, unknown): “This signaling event restricts the activity of T helper 17 (TH17) cells and not only promotes B. fragilis colonization but also suppresses Helicobacterhepaticus–inducedcolitis (67,68).”
The first 1000 cultured species of the human gastrointestinal microbiota (2014, background): “…cultures of Bacteroides spp., is a result of the recognition and selection by the immune system of the host (Rakoff-Nahoum et al., 2004), mediated through the toll-like receptors (Round et al., 2011; Lopez-Siles et al., 2012) and other specific host-microorganism interactions (Hooper et al., 2012).”
Holobionts as Units of Selection and a Model of Their Population Dynamics and Evolution (2018, background): “These include the activation of pattern recognition receptors (PRRs; Chu and Mazmanian 2013) and Toll-like receptors (Round et al. 2011), and the subsequent induction of regulatory T lymphocytes (Sefik et al.”
The First Microbial Colonizers of the Human Gut: Composition, Activities, and Health Implications of the Infant Gut Microbiota (2017, background): “(TLRs) (404) and other specific microbe-host interactions (427).”
The Impact of the Gut Microbiota on Human Health: An Integrative View (2012, unknown): “When TLRs are not present or are mutated, the gut and mucosal immune systems do not form normally (O'Hara and Shanahan, 2006).”
Understanding the Holobiont: How microbial metabolites affect human health and shape the immune system (2017, background): “Cobb et al., 2004; Dasgupta et al., 2014; Johnson et al., 2015; Mazmanian et al., 2008; Round et al., 2011 Review et al., 2008).”
The role of gut microbiota in immune homeostasis and autoimmunity (2012, background): “fragilis can signal through TLR2 on Tregs to subsequently suppress a Th17 response.(45) Lathrop et al.”
Resistance Mechanisms to Immune-Checkpoint Blockade in Cancer: Tumor-Intrinsic and -Extrinsic Factors. (2016, unknown): “Components of the microbiota also facilitate Treg cell induction and function (e.g., IL-10 production)— this was first documented for polysaccharide A (PSA) produced by the prominent human symbiont Bacteroides fragilis (Mazmanian et al., 2008; Round et al., 2011).”
Microbiome and Malignancy (2011, background): “Members of the human microbiota can suppress aspects of cellular immunity (e.g.: B. fragilis (Mazmanian et al., 2008; Round et al., 2011) whereas others (e.g. cagA+ H pylori) induce pro-inflammatory cytokines (Backert and Selbach, 2008).”