SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected Patients

By L. Zou, Feng Ruan, Mingxing Huang, L. Liang, Huitao Huang, Z. Hong, Jianxiang Yu, Min Kang, Yingchao Song, J. Xia and 6 more. New England Journal of Medicine, 2020

4,546 citations recorded by the source corpus.

SARS-CoV-2 Viral Load in Upper Respiratory Specimens The authors report results of an analysis of nasal and throat swabs from 17 patients in Zhuhai, China, who had received a diagnosis of Covid-19....

Subfields: Epidemiology, Infectious Diseases, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/5afa72bc655692de39ead507013ab6bb82f42a05

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Citations in the corpus

Epidemiologic Features and Clinical Course of Patients Infected With SARS-CoV-2 in Singapore. (2020, neutral): “Duration of symptoms, median (range) Fever, d 4 (0-15) 1 (0-7) 5 (4-15) Any symptoms, d 13 (5-24) 12 (5-24) 16 (10-20) Abbreviations: LDH, lactate dehydrogenase; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; WBC, white blood cell.”
Spread and dynamics of the COVID-19 epidemic in Italy: Effects of emergency containment measures (2020, result): “Moreover, the viral load of symptomatic cases is reportedly similar to that of the asymptomatic (81).”
Estimating the asymptomatic proportion of coronavirus disease 2019 (COVID-19) cases on board the Diamond Princess cruise ship, Yokohama, Japan, 2020 (2020, background): “org similarity in viral loads between asymptomatic and symptomatic patients [14] and that transmission of SARS-CoV-2 by asymptomatic or paucisymptomatic cases may be possible, even though there is no clear evidence as yet of asymptomatic transmission, the relatively high proportion of asymptomatic i”
Smell dysfunction: a biomarker for COVID‐19 (2020, methodology): “Subsequently, the diagnosis of COVID-19 disease was confirmed by quantitative detection of SARS-CoV-2 RNA using the real-time reverse transcription polymerase chain reaction (rRT-PCR) in respiratory specimens.(14) The RT-PCR assays were performed using Sansure Biotech's 2019-nCoV 30-Minute Nucleic A”
Heightened Innate Immune Responses in the Respiratory Tract of COVID-19 Patients (2020, neutral): “Nevertheless, high SARSCoV-2 loads were detected very early after symptom onset (Zou et al., 2020), suggesting that the virus may have developed countermeasures against the IFN system such as delaying the IFN response by inhibiting innate immune signaling.”
Epidemiology and transmission of COVID-19 in 391 cases and 1286 of their close contacts in Shenzhen, China: a retrospective cohort study (2020, background): “We considered periods where the mean infectious day is less than 15 days after symptom onset (roughly the period of SARS and early SARS-CoV-2 reports 16, 17 ) , and assumed that R=2·6 and that isolation effectively ends the infectious period.”
SARS-CoV-2: an Emerging Coronavirus that Causes a Global Threat (2020, positive): “Consistently, a study found that an asymptomatic patient had a similar vial loads in the samples of nasal and throat swabs to that of the symptomatic patients [48].”
Asymptomatic and Presymptomatic SARS-CoV-2 Infections in Residents of a Long-Term Care Skilled Nursing Facility — King County, Washington, March 2020 (2020, neutral): “Similar Ct values were reported in asymptomatic adults in China who were known to transmit SARS-CoV-2 (9).”
The coronavirus pandemic and aerosols: Does COVID-19 transmit via expiratory particles? (2020, background): “In China, Chan et al. (2020), Zou et al. (2020), and Hu et al. (2020) all reported the existence of asymptomatic individuals who tested positive for the SARS-CoV-2, and virus transmissions from asymptomatic carriers have been identified (Rothe et al. 2020).”
Occurrence and transmission potential of asymptomatic and presymptomatic SARS-CoV-2 infections: A living systematic review and meta-analysis (2020, neutral): “The remaining studies, in hospital settings, included adult patients only (15 studies, n = 3,228) [27,39,45,52,53,56,57,64,80,83,89,92,103,107,114], children only (10 studies, n = 285) [40–42,59,84,87,98,99,104,106], or adults and children (10 studies, n = 1,518) [54,67,77,79,86,88,96,102,109,112] (”
Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study (2020, background): “Referring to the studies that have demonstrated that the viral load was significantly decreased after 14 days [11] , we assessed the short-term olfaction non-recovery rate on patients exhibiting double criteria: an onset of the infection > 14 days before the assessment and the lack of general sympto”