Macrophage polarization and function with emphasis on the evolving roles of coordinated regulation of cellular signaling pathways.

By Dexi Zhou, Cheng Huang, Zhen Lin, Shuxiang Zhan, Lingna Kong, Chengbo Fang, Jun Li. Cellular Signalling, 2014

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The Reactive Oxygen Species in Macrophage Polarization: Reflecting Its Dual Role in Progression and Treatment of Human Diseases (2016, background): “Inmany human diseases, macrophages detect tissue injury or infections and process the damage or remodeling of wounded tissues [3].”
TNF and TNF-receptors: From mediators of cell death and inflammation to therapeutic giants - past, present and future. (2014, background): “vely activated and largely tolerogenic M2 cell-subtype [143,144].”
Alternatively activated microglia and macrophages in the central nervous system. (2015, background): “Mechanisms of macrophage polarization The signaling mechanisms engaged in macrophage polarization are starting to be elucidated (for review see Zhou et al., 2014). induce the classical (M1) or the alternative (M2) activation pathways are indicated ithin the M2 polarized cell group (likely as an…”
Progress in tumor-associated macrophage (TAM)-targeted therapeutics (2017, neutral): “As such, macrophages are an important potential therapeutic target[26][34].”