Sox9 induces testis development in XX transgenic mice

By V. Vidal, Marie-Christine Chaboissier, D. G. Rooij, A. Schedl. Nature Genetics, 2001

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Somatic sex reprogramming of adult ovaries to testes by FOXL2 ablation. (2009, neutral): “, 1999), a situation that reflects experimental manipulation of mice where complete XX sex reversal can be achieved by ectopic expression in the developing XX gonad of SRY or SOX9, or of other SOX proteins that mimic these (Bishop et al., 2000; Koopman et al., 1991; Vidal et al., 2001).”
Sex determination and gonadal development in mammals. (2007, background): “Transgenic mice that express Sox9 under the control of the Wt1 promoter (241), and a mutant strain of mice, Odd Sex, in which Sox9 fails to be normally downregulated in XX development (192) both show XX sex reversal, suggesting that Sox9 is the only target of SRY and is able to fulfill all its funct”
R-spondin1 is essential in sex determination, skin differentiation and malignancy (2006, background): “In animal models, XX sex reversal has been artificially produced only by the ectopic expression of the testis-determining genes Sry and Sox9 in the developing XX gonad”
Depletion of definitive gut endoderm in Sox17-null mutant mice. (2002, background): “…the Sertoli cells and the formation of the testis [Sry (Koopman et al., 1991); Sox9(Foster et al., 1994; Wagner et al., 1994; Bishop et al., 2000; Vidal et al., 2001)], lens formation [Sox1(Kamachi et al., 1998; Nishiguchi et al., 1998)], pro-B-lymphocyte proliferation [Sox4(Schilham et al.,…”