The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation.
By Alexander Hoffmann, Andre Levchenko, M. Scott, David Baltimore. Science, 2002
916 citations recorded by the source corpus.
View Paper: https://www.semanticscholar.org/paper/5a50f57ec97098796731b73101ec74a1600da947
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
- M. Hayden
- S. Ghosh
- Réka Albert
- David Baltimore
- Alexander Hoffmann
- Robert J. Prill
- Raymond Cheong
- Pablo A. Iglesias
Citations in the corpus
- NF-κB activation as a pathological mechanism of septic shock and inflammation (2006, unknown): “I B appears to function as a strong negative feedback mechanism that allows a fast turn-off of the NF- B response, whereas I B and I B function to reduce systemic oscillation and stabilize the NF- B response during longer stimulation (97).”
- Scale-free networks in cell biology (2005, methodology): “In the absence of comprehensive time-course datasets, dynamic reconstruction and analysis can usually be carried out only for small networks (Hoffmann et al., 2002; Lee et al., 2003; Tyson et al., 2001).”
- Information transduction capacity of noisy biochemical signaling networks (2011, background): “1D), choosing this time point because NF-κ B translocation peaks at 30 min. regardless of the concentration used, initiating expression of early response inflammatory genes (19–22).”
- Regulation of NF-κB by TNF Family Cytokines (2014, methodology): “Negative feedback resulting from TNFinduced expression of IκB proteins determines the periodicity and amplitude of the NF-κB responses occurring during sustained stimulation [103].”
- Encoding and Decoding Cellular Information through Signaling Dynamics (2013, unknown): “Knockout mouse embryonic fibroblasts (MEFs) lacking NF-kB’s negative regulator, IkBa, show sustained rather than transient NF-kB activity upon TNFa treatment (Hoffmann et al., 2002).”
- Dynamic Properties of Network Motifs Contribute to Biological Network Organization (2005, background): “For example, relatively short stimulations by tumor necrosis factor a (5 min or less) can trigger sustained (60 min) activation of the NF-jB pathway leading to expression of a battery of genes [22].”
- Circuitry of nuclear factor κB signaling (2006, methodology): “Efforts to reconstruct these mechanisms in computational models (14, 24, 67) provide the tools to explore their overlapping and distinct functions in attenuating NF-kB activity.”