High speed of fork progression induces DNA replication stress and genomic instability

By A. Maya-Mendoza, Pavel Moudrý, J. Merchut-Maya, Myunghee Lee, R. Strauss, J. Bartek. 2018

468 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Johannes C. Walter
2. Masato T. Kanemaki
3. Sachiko Muramatsu

In Oncology

1. Masato T. Kanemaki

Citations in the corpus

• In silico protein interaction screening uncovers DONSON’s role in replication initiation (2023, background): “Indeed,knock-downofMTBPorTRESLIN, which act upstream of DONSON, reduces origin firing and increases fork rates, but unlike DONSON, does not cause fork asymmetry ( 11 , 12 , 47 ).”
• PARP Inhibitors: Clinical Relevance, Mechanisms of Action and Tumor Resistance (2020, background): “This suggests an underlying mechanism of PARPi toxicity could be the result of DSBs occurring as a result of high-speed replication (Maya-Mendoza et al., 2018; Quinet and Vindigni, 2018).”
• ROS and the DNA damage response in cancer (2018, background): “results in genomic instability and paves the way for tumor development through the accumulation of additional pro-carcinogenic changes [28,30].”