Association between mitochondrial dysfunction and severity and outcome of septic shock.

By D. Brealey, M. Brand, I. Hargreaves, S. Heales, J. Land, R. Smoleński, N. Davies, Chris E. Cooper, Mervyn Singer. The Lancet, 2002

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The microcirculation is the motor of sepsis (2005, background): “Brealey and colleagues [33] showed that mitochondrial dysfunction indeed plays an important role in sepsis where the level of respiratory dysfunction of mitochondria correlated with patient outcome.”
Mechanisms of sepsis-induced cardiac dysfunction (2007, background): “This is related to elevated production of superoxide and NO and depletion of intramitochondrial antioxidants (74).”
Clinical review: intensive care unit acquired weakness (2015, background): “The muscles of septic patients show signs of bioenergetic failure, comprising oxidative stress, mitochondrial dysfunction, and ATP depletion [34].”
Nitric oxide and peroxynitrite in health and disease. (2007, background): “In septic patients, a decrease in tissue ATP levels and mitochondrial complex I activity was measured in skeletal muscle biopsies, which correlated with increased clinical severity and NO production within muscles, supporting a critical role of NO-peroxynitrite in the suppression of mitochondrial re”