Sedentary behaviour and risk of all-cause, cardiovascular and cancer mortality, and incident type 2 diabetes: a systematic review and dose response meta-analysis
By Richard Patterson, E. McNamara, M. Tainio, T. H. de Sá, A. Smith, S. Sharp, P. Edwards, J. Woodcock, Søren Brage, K. Wijndaele. European Journal of Epidemiology, 2018
1,185 citations recorded by the source corpus.
Purpose: To estimate the strength and shape of the dose–response relationship between sedentary behaviour and all-cause, cardiovascular disease (CVD) and cancer mortality, and incident type 2 diabetes (T2D), adjusted for physical activity (PA). Data Sources: Pubmed, Web of Knowledge, Medline, Embase, Cochrane Library and Google Scholar (through September-2016); reference lists. Study Selection: Prospective studies reporting associations between total daily sedentary time or TV viewing time, and ≥ one outcome of interest. Data Extraction: Two independent reviewers extracted data, study quality was assessed; corresponding authors were approached where needed. Data Synthesis: Thirty-four studies (1,331,468 unique participants; good study quality) covering 8 exposure-outcome combinations were included. For total sedentary behaviour, the PA-adjusted relationship was non-linear for all-cause mortality (RR per 1 h/day: were 1.01 (1.00–1.01) ≤ 8 h/day; 1.04 (1.03–1.05) > 8 h/day of exposure), and for CVD mortality (1.01 (0.99–1.02) ≤ 6 h/day; 1.04 (1.03–1.04) > 6 h/day). The association was linear (1.01 (1.00–1.01)) with T2D and non-significant with cancer mortality. Stronger PA-adjusted associations were found for TV viewing (h/day); non-linear for all-cause mortality (1.03 (1.01–1.04) ≤ 3.5 h/day; 1.06 (1.05–1.08) > 3.5 h/day) and for CVD mortality (1.02 (0.99–1.04) ≤ 4 h/day; 1.08 (1.05–1.12) > 4 h/day). Associations with cancer mortality (1.03 (1.02–1.04)) and T2D were linear (1.09 (1.07–1.12)). Conclusions: Independent of PA, total sitting and TV viewing time are associated with greater risk for several major chronic disease outcomes. For all-cause and CVD mortality, a threshold of 6–8 h/day of total sitting and 3–4 h/day of TV viewing was identified, above which the risk is increased.
Subfields: Physiology, Public Health, Environmental and Occupational Health
View Paper: https://www.semanticscholar.org/paper/ad0ddb3e0e2195b770a6e6b8da83b4b8af52c72f
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Citations in the corpus
- Effects of COVID-19 Home Confinement on Eating Behaviour and Physical Activity: Results of the ECLB-COVID19 International Online Survey (2020, background): “[26] suggested causes an increase in disease and mortality risks.”
- Canadian 24-Hour Movement Guidelines for Adults aged 18-64 years and Adults aged 65 years or older: an integration of physical activity, sedentary behaviour, and sleep. (2020, methodology): “5 h/day for daily sedentary behaviour (Chau et al. 2013; Ku et al. 2018, 2019; Patterson et al. 2018; Ekelund et al. 2019), with lower thresholds generally observed for selfreported sedentary behaviour and higher thresholds for devicemeasured sedentary time (Ku et al.”
- A tale of two pandemics: How will COVID-19 and global trends in physical inactivity and sedentary behavior affect one another? (2020, background): “Increased sitting time/SB, independent of leisure time PA, has also been convincingly shown to be a significant predictor of adverse health outcomes.(13,14) It has been estimated that each additional hour of sitting time results in an increase of $126 in annual healthcare costs in older adults.”