Yeast Genes That Enhance the Toxicity of a Mutant Huntingtin Fragment or α-Synuclein

By S. Willingham, T. Outeiro, M. Devit, Susan Lindquist, P. Muchowski. Science, 2003

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Intravesicular Localization and Exocytosis of α-Synuclein and its Aggregates (2005, background): “In agreement with its interaction with lipid membranes and localization in vesicles, -syn has been implicated in lipid metabolism and vesicle trafficking (Scherzer et al., 2003; Willingham et al., 2003).”
Anti-apoptosis and cell survival: a review. (2011, background): “more sensitive to the apoptotic inducing effects of the Parkinson's associated α-synuclein [314].”
Modulation of neurodegeneration by molecular chaperones (2005, background): “In fruitfly and yeast screens several HSP40 homologues have been identified as potent suppressors of polyQ-mediated toxicit”
α-Synuclein in Parkinson's disease. (2012, background): “In a blinded screen in a yeast model, the major class of modulators ofa-synuclein toxicity was genes involved in vesicular trafficking (Willingham et al. 2003).”
Parkinson's disease: genetics and pathogenesis. (2011, background): “Expression of human α-synuclein is toxic in yeast (139, 140), nematodes (141), and fruit flies (142).”