LAT Is Essential for FcεRI-Mediated Mast Cell Activation

By S. Saitoh, R. Arudchandran, T. Manetz, Weiguo Zhang, C. Sommers, P. Love, J. Rivera, L. Samelson. 2000

356 citations recorded by the source corpus.

Subfields: Immunology, Radiology, Nuclear Medicine and Imaging, Rheumatology

View Paper: https://www.semanticscholar.org/paper/598fa54b9529091f0bb150b1557d583cef41d06d

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In Immunology

1. C. Lowell

Citations in the corpus

• Scaffolding Adapter Grb2-Associated Binder 2 Requires Syk to Transmit Signals from FcεRI1 (2006, background): “The Lyn/Syk/LAT pathway and the alternative pathway involving Fyn/Gab2/PI3K have been suggested to play critical roles in Fc RI-evoked degranulation of mast cells (2).”
• Transmembrane adaptor proteins: organizers of immunoreceptor signalling (2004, background): “Signalling through the high-affinity receptor for IgE (FceRI) is markedly reduced in LAT-deficient mast cell”
• Integrated signalling pathways for mast-cell activation (2006, background): “org/molecule/query?afcsid=A001392">LAT (linker for activation of T cells) is crucial for coordination of the downstream signalling pathways that are required for the release of the various pro-inflammatory mediator”