Transmembrane adaptor proteins: organizers of immunoreceptor signalling

By V. Hořejší, Weiguo Zhang, B. Schraven. Nature reviews. Immunology, 2004

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A methodology for the structural and functional analysis of signaling and regulatory networks (2006, background): “• Activated PLCγ1 hydrolyses phosphatidyl-inositol-4,5 biphosphate (PIP2), which is considered an ubiquitous membrane associated phospholipid and is therefore not modeled, thereby generating the second messenger molecules diacyloglycerol (DAG) and inositol trisphosphate (IP3) [59,61].”