Structural basis for the autoinhibition of c-Abl tyrosine kinase.
By B. Nagar, O. Hantschel, M. Young, K. Scheffzek, D. Veach, W. Bornmann, B. Clarkson, G. Superti‐Furga, J. Kuriyan. Cell, 2003
841 citations recorded by the source corpus.
Subfields: Ecology, Evolution, Behavior and Systematics, Hematology, Organic Chemistry
View Paper: https://www.semanticscholar.org/paper/59409f8edfa80ddfe2af00ff2c490bef8fb9850c
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Citations in the corpus
- Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl. (2005, methodology): “Crystallographic studies revealed that imatinib binds to Bcr-Abl by filling a pocket created in the ATP binding site by the DFG motif of the activation loop being displaced from the position that it occupies in the catalytically active conformation of the enzyme (Schindler et al., 2000; Nagar et al.”
- Synthetic protein scaffolds provide modular control over metabolic flux (2009, background): “These machineries (protein-protein interaction domains and their ligands) are used in many different combinations in natural proteins to achieve different behavior”
- Activation of Abl tyrosine kinases promotes invasion of aggressive breast cancer cells. (2006, background): “c-Abl is negatively regulated by intramolecular interactions: the kinase domain binds a NH2terminal myristoyl residue (7), and the SH3 domain interacts with proline residues in the interlinker region (between SH2 and kinase domains; ref.”
- Sequence-similar, structure-dissimilar protein pairs in the PDB (2007, background): “The presence of the kinase domain in one structure locks the SH2 domain in a specific conformation in relation to the SH3 domain,26 resulting in an RMSD of 9.5 A˚ to the second structure, which lacks the kinase domain.”
- Structure and regulation of Src family kinases (2004, background): “Thus, the myristoylated N-terminus functionally replaces the SH2–tail interaction in Abl, and, as in Src, disruption of this latch leads to oncogenic activation (Azam et al., 2003; Hantschel et al., 2003; Harrison, 2003; Nagar et al., 2003).”