Functional improvement of dystrophic muscle by myostatin blockade

By S. Bogdanovich, T. Krag, E. Barton, Linda D. Morris, Lisa-Anne Whittemore, R. Ahima, T. Khurana. Nature, 2002

867 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/590fb54cd1f2d89d44f4e1ad999be802dc756277

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In Cellular and Molecular Neuroscience

1. D. Glass
2. J. Hawley
3. Vernon G. Coffey

In Molecular Biology

1. K. Fearon
2. D. Glass
3. D. Guttridge
4. J. Hawley
5. Vernon G. Coffey

In Physiology

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2. D. Glass

Citations in the corpus

• Myostatin Signals through a Transforming Growth Factor β-Like Signaling Pathway To Block Adipogenesis (2003, background): “Myostatin-null mice display widespread increases in muscle mass (36) and decreased body fat accumulation (28, 38), and inhibition of myostatin with blocking antibodies increases muscle mass (8).”
• Angiotensin II type 1 receptor blockade attenuates TGF-β–induced failure of muscle regeneration in multiple myopathic states (2007, background): “Myostatin antagonism has been shown to ameliorate the muscle phenotype in dystrophin-deficient mdx mic”
• Cancer cachexia: mediators, signaling, and metabolic pathways. (2012, background): “, 2002), and conversely, inhibition by various genetic means promotes a doubling in muscle mass and myofiber size (Bogdanovich et al., 2002; Whittemore et al., 2003; Lee et al., 2005; Welle et al., 2007).”
• Exercise is the real polypill. (2013, background): “Although myostatin increases might contribute to insulin resistance (184, 360), obesity (185), muscle wasting (63, 70, 97, 154), or agingsarcopenia (523), its loss/inhibition decreases adiposity (164, 303, 521, 530), induces browning of the white adipose tissue [through AMPK-peroxisome proliferator-”
• Myostatin negatively regulates satellite cell activation and self-renewal (2003, background): “Also, the injection of a specific antibody to Myostatin into the mdx mice alleviated the severity of the phenotype; in fact, the mice gained muscle mass and increased the production of the muscle protein creatine kinase, indicating improvement of muscle strength (Bogdanovich et al., 2002).”
• The molecular basis of skeletal muscle atrophy. (2004, background): “It appears that mdx mice injected with myostatin antibodies for 3 mo showed an increase in muscle mass (11).”