Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells

By S. Piccirillo, B. Reynolds, N. Zanetti, G. Lamorte, Elena Binda, G. Broggi, H. Brem, A. Olivi, F. DiMeco, Angelo Luigi Vescovi. Nature, 2006

1,215 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/58b50262471a694103f129f68508c4189af5f363

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In Molecular Biology

1. V. Plaks
2. Zena Werb
3. Niwen Kong
4. Jane E. Visvader
5. R. DePinho
6. S. Morrison
7. T. Schatton
8. M. Frank

In Oncology

1. Zena Werb
2. V. Plaks
3. Jane E. Visvader
4. Niwen Kong
5. Jeremy N. Rich
6. G. Lindeman
7. R. DePinho
8. T. Schatton

Citations in the corpus

• Integrin alpha 6 regulates glioblastoma stem cells (2010, background): “GSCs activate a number of key stem cell signaling pathways, including Akt, bone morphogenetic protein, c-myc, hypoxia response, Notch, and Sonic Hedgehog (Bar et al., 2007; Eyler et al., 2008; Fan et al., 2006; Li et al., 2009; Piccirillo et al., 2006; Wang et al., 2008b).”
• Heterogeneity in cancer: cancer stem cells versus clonal evolution. (2009, neutral): “Consistent with the model, cancer stem cells differentiate into nontumorigenic cancer cells in germ lineage cancers (Kleinsmith and Pierce, 1964; Illmensee and Mintz, 1976), chronic myeloid leukemia (O’Hare et al., 2006), and some brain tumors (Piccirillo et al., 2006).”
• P53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation (2008, positive): “The diminished tumorigenicity of these TICs upon restoration of differentiation potential, along with recent reports supporting pro-differentiation as a potential strategy to inhibit GBM-derived TICs 29, 30 , encourages the identification and testing of agents targeting these differentiation pathway”
• CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells (2008, background): “In brain tumors, CD133 positive tumor-initiating cells have been identified that proliferate in serum-restricted medium, and differentiate into nonproliferative cells, expressing markers of mature cells after adding serum or bone morphogenetic proteins.(11,43) However, most glioma cell lines and pri”
• The Cancer Stem Cell Niche: How Essential is the Niche in Regulating Stemness of Tumor Cells? (2015, positive): “Similarly, mouse glioblastoma stem cells can be induced to differentiate into glia by treatment with the protein BMP4, resulting in reduced proliferation, tumor growth, and tumor-initiation capability of CSCs upon transplantation (Lombardo et al., 2011; Piccirillo et al., 2006).”
• Expression profiling of ependymomas unravels localization and tumor grade‐specific tumorigenesis (2009, background): “BMP4 has been detected in advanced stages of colorectal cancer(28); whereas, in glioblastomas, BMP4 overexpression was associated with tumor regression.(29) Conversely, the BMP4 target genes ID1 and ID2 were highly expressed in aggressive astrocytic tumors.”
• Transparent adult zebrafish as a tool for in vivo transplantation analysis. (2008, background): “These rare cells, which are thought to form the seed from which all other tumor cells arise, have been isolated by selecting for cells (i.e., CD133+) that can be repeatedly propagated in serial transplantation studies ( Piccirillo et al., 2006 ).”