Lysyl oxidase: Properties, specificity, and biological roles inside and outside of the cell
By H. Kagan, Wande Li. Journal of Cellular Biochemistry, 2003
964 citations recorded by the source corpus.
Subfields: Molecular Biology, Pathology and Forensic Medicine
View Paper: https://www.semanticscholar.org/paper/584f219b27d413d36c6210e34974b70559aa6310
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In Molecular Biology
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In Pathology and Forensic Medicine
Citations in the corpus
- Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin signaling (2009, background): “To rule out any direct effect of LOX activity on MEC behavior, we also treated a cohort of animals in parallel (i.e., at time of MEC injection) with b-aminopropionitrile (BAPN), a natural and irreversible inhibitor of lysyl oxidase activity (Kagan and Li, 2003).”
- Allosteric inhibition of lysyl oxidase–like-2 impedes the development of a pathologic microenvironment (2010, background): “Enzymes that modify the extracellular matrix include lysyl oxidases, a family of five enzymes sharing a conserved enzymatic domain with divergent N termin”
- Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the pre-metastatic niche (2009, background): “LOX is known to crosslink collagens and elastins in the extracellular matrix (Kagan and Li, 2003), thereby increasing the tensile strength of basement membranes (Maki et al.”
- Hypoxia-Inducible Factor 1α Induces Fibrosis and Insulin Resistance in White Adipose Tissue (2009, background): “LOX facilitates cross-linking and stabilization of collagens and elastins in the extracellular space and, thereby, increases insoluble matrix deposition and tensile strength (25).”
- Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition. (2007, background): “Lysyl oxidases are copper-dependent enzymes with intracellular and extracellular activities that catalyze the oxidation of lysine residues in collagen and elastin and can modulate cell migration (34, 35).”
- Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer (2011, positive): “Clinical manifestations of reduced LOX activity (which can result from nutritional copper assimilation deficiencies) are also seen in two X-linked recessively inherited disorders: Menkes disease and occipital horn syndrome (OHS) (Royce et al., 1980; Kaler et al., 1994).”