Aspirin and the risk of colorectal cancer in relation to the expression of COX-2.

By A. Chan, S. Ogino, C. Fuchs. New England Journal of Medicine, 2007

770 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/584bba47d4f0e54c45f656990d6ed614d171a23d

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Citations in the corpus

Eicosanoids and cancer (2010, background): “Therapeutic and chemopreventive agents A retrospective cohort study shows that aspirin, a non-selective NSAID, specifically reduces cancer risk in the subgroup of patients whose colon tumours expressed higher levels of COX2 (Ref”
Cancer-related inflammation (2008, background): “Accordingly, treatment with non-steroidal anti-inflammatory agents decreases the incidence of, and the mortality that results from, several tumour type”
CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer (2008, methodology): “We collected paraffinembedded tissue blocks from hospitals where patients underwent resections of primary colon cancers.[31] Tissue sections from all cases in this study were reviewed by a pathologist (S.”
Genomic Correlates of Immune-Cell Infiltrates in Colorectal Carcinoma (2016, methodology): “We constructed tissue microarrays (TMAs) when tissue was sufficient (Chan et al., 2007).”
The Role of COX-2 in Intestinal Inflammation and Colorectal Cancer (2009, unknown): “Aspirin use was associated with a risk reduction in patients whose colon tumors expressed higher levels of COX-2 (Chan et al., 2007).”
Aspirin Use, Tumor PIK3CA Mutation, and Colorectal-Cancer Survival (2012, unknown): “Rectum 212/961 (22) 118/465 (25) 70/335 (21) 14/95 (15) 10/66 (15)”
T Regulatory Cells: Key Players in Tumor Immune Escape and Angiogenesis (2012, background): “aspirin, are significantly less likely to develop colorectal cancer (76, 77), and several investigators have shown an adjuvant property of COX-2 inhibitors in combination with cancer vaccines (78–80).”
Effect of Aspirin on All-Cause Mortality in the Healthy Elderly (2018, background): “Other race or ethnic group was defined as any category with less than 200 participants overall, which included Aboriginal or Torres Strait Islander (12 participants), Native American (6), multiple races or ethnic groups (64), Native Hawaiian or Pacific Islander (11), and those who indicated that the”
Wnt signaling in cancer. (2012, background): “…involving the use genetically engineered mouse models of cancer, as well as expansive human studies on nonsteroidal anti-inflammatory drugs (NSAIDS) and cancer risk, have firmly established a role for prostaglandin signaling in colorectal tumorigenesis (Oshima and Taketo 2002; Chan et al. 2007).”