Non-invasive imaging of human embryos before embryonic genome activation predicts development to the blastocyst stage

By Connie C. S. Wong, K. Loewke, N. Bossert, B. Behr, C. Jonge, T. Baer, R. R. Pera. Nature Biotechnology, 2010

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Assessing efficacy of day 3 embryo time-lapse algorithms retrospectively: impacts of dataset type and confounding factors (2019, methodology): “…of time-lapse technology appeared to be a promising tool in optimizing embryo selection at the cleavage stage, due to its non-invasive nature, uninterrupted culture environment, and the large amounts of dynamic morphological information captured (Meseguer et al., 2011; Wong et al., 2010).”
The use of morphokinetics as a predictor of embryo implantation. (2011, background): “In a more recent study, Wong et al. (2010) found that development of human embryos to the blastocyst stage was correlated with: (i) the duration of the first cytoplasmic cleavage from 1 cell to 2 cells; (ii) time between division to 2 cells and subsequent division to 3 cells and (iii) time between…”
Time-lapse deselection model for human day 3 in vitro fertilization embryos: the combination of qualitative and quantitative measures of embryo growth. (2016, methodology): “Briefly, [1] if one was determined to be a poor-quality embryo (PQE) according to conventional morphology assessment at 68 hpi, it is categorized a grade F, otherwise subject to further criteria; [2] if one had displayed abnormal cleavage pattern(s) such as DC, RC, or <6 ICCP at the end of the 4-cel”