Sampling the Antibiotic Resistome

By Vanessa M. D’Costa, Katherine M McGrann, D. Hughes, Gerard D. Wright. Science, 2006

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Embracing the unknown: disentangling the complexities of the soil microbiome (2017, background): “…with other soil microbial taxa (as exemplified by the widespread occurrence of antibiotic-producing and antibiotic-resistant soil bacteria 12 ), frequent disturbances (for example, drying–rewetting events, predation by earthworms and other fauna, and freezing– thawing), and an uneven…”
Origins of bacterial diversity through horizontal genetic transfer and adaptation to new ecological niches. (2011, neutral): “(Riesenfeld et al., 2004; D’Costa et al., 2006).”
Dissemination of Antimicrobial Resistance in Microbial Ecosystems through Horizontal Gene Transfer (2016, background): “…number of such studies have revealed a huge number of previously unknown ARGs present in environments such as soil (Riesenfeld et al., 2004; D’Costa et al., 2006; Allen et al., 2009; Frontiers in Microbiology | www.frontiersin.org 2 February 2016 | Volume 7 | Article 173 Donato et al.,…”
Mechanisms of multidrug resistance in Acinetobacter species and Pseudomonas aeruginosa. (2006, background): “[130], the soil was demonstrated to be a reservoir of resistance genes (the “antibiotic resistome”).”
The antibiotic resistome: the nexus of chemical and genetic diversity (2007, background): “We have proposed that the collection of all the antibiotic resistance genes in microorganisms be known as the antibiotic resistome”