Positional cloning of heart and soul reveals multiple roles for PKCλ in zebrafish organogenesis

By S. Horne-Badovinac, D. Lin, S. Waldron, M. Schwarz, G. Mbamalu, Tony Pawson, Y. Jan, D. Stainier, S. Abdelilah‐Seyfried. 2001

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PTEN-mediated apical segregation of phosphoinositides controls epithelial morphogenesis through Cdc42. (2007, background): “Mutation of zebrafish aPKCl causes defects in lumen formation in the intestine (Horne-Badovinac et al., 2001).”
A 90° rotation of the mitotic spindle changes the orientation of mitoses of zebrafish neuroepithelial cells (2003, background): “…animal species [for example in the cerebral cortex of the mouse (Smart, 1973) and ferret (Chenn and McConnell, 1995) and in the retina of the rat (Cayouette et al., 2001) or the zebrafish (Horne-Badovinac et al., 2001)], mitoses show a variety of orientations with respect to the neuroepithelium.”
Tight junctions and cell polarity. (2006, background): “Moreover, the zebrafish homolog of aPKC, Heart and Soul, is required for the formation and maintenance of the ZA during early epithelial development in zebrafish (Horne-Badovinac et al. 2001).”
A molecular network for de novo generation of the apical surface and lumen (2010, background): “Apical membrane traffic might be needed to localize proteins that orient mitosis, such as Cdc42, aPKC and LGN (leucine-glycine-asparagine repeat-containing protein”
Cellular and molecular analyses of vascular tube and lumen formation in zebrafish (2005, methodology): “Microinjections of Morpholinos (MO) were performed as previously described (Nasevicius and Ekker, 2000; Horne-Badovinac et al., 2001).”