Pharmacological inhibition of endocytic pathways: is it specific enough to be useful?

By A. Ivanov. Methods in molecular biology, 2008

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Cell‐penetrating peptides: 20 years later, where do we stand? (2013, background): “line used and even sometimes decrease in cell viability [146,147].”
Endocytosis of Nanomedicines (2010, background): “This can be achieved, for example, using various pharmacologic inhibitors of endocytosis that include chemical or biological agents [24,25].”
The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles (2012, neutral): “This includes inhibition of more than one route due to low specificity of the inhibitors, uptake by compensatory mechanisms when one route is blocked, alterations of plasma-membrane proteins, disruption of the cortical actin cytoskeleton, and inhibition of vesicle trafficking, etc.(166) The cell-spe”