FGF‐23 Is a Potent Regulator of Vitamin D Metabolism and Phosphate Homeostasis
By T. Shimada, H. Hasegawa, Y. Yamazaki, T. Muto, Rieko Hino, Y. Takeuchi, T. Fujita, K. Nakahara, S. Fukumoto, T. Yamashita. Journal of Bone and Mineral Research, 2003
1,814 citations recorded by the source corpus.
Subfields: Endocrinology, Diabetes and Metabolism, Nephrology, Pathology and Forensic Medicine
View Paper: https://www.semanticscholar.org/paper/57f287f2a76f520e4726b2168b164b182e6280c7
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Citations in the corpus
- Molecular Mechanisms of Vitamin D Action (2012, background): “CYP24A1 is induced by FGF23 [41] as well as by the 1,25D hormone, with potent VDREs identified in the CYP24A1 gene (Table 1).”
- Calcium and phosphorus metabolism in broilers: Effect of homeostatic mechanism on calcium and phosphorus digestibility1 (2013, background): “It has been reported that single injection of FgF23 in mice led to suppression of P, PTH, and 1,25(oH)2d3 serum concentration, as well as to decreased renal Na-P IIa and 25(oH)d3 1α-hydroxylase mRNA [196, 197].”
- Vitamin D and human health: lessons from vitamin D receptor null mice. (2008, background): “Like PTH, FGF23 can suppress expression of Na/Pi-2a and Na/Pi-2c cotransporters (219, 220).”
- Structural basis for fibroblast growth factor receptor activation. (2005, background): “In the adult, FGFs continue to regulate tissue homeostasis but also play important roles in wound healing, tissue repair, cholesterol metabolism [47,48] and serum phosphate regulation [49–54].”
- Fibroblast growth factor-23 mitigates hyperphosphatemia but accentuates calcitriol deficiency in chronic kidney disease. (2005, background): “Indeed, intravenous or intraperitoneal infusion of recombinant FGF-23 in mice induces phosphaturia and hypophosphatemia (30,31), and transgenic mice expressing FGF-23 under the control of different promoters develop hypophosphatemia and rickets (32–34).”
- Fibroblast growth factor 23 is a counter-regulatory phosphaturic hormone for vitamin D. (2006, background): “In this regard, VDR null mice have low circulating FGF23 levels (35), and 1,25(OH)2D3 administration stimulates FGF23 levels in mice independent of PTH (35,38).”
- Vitamin D, effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease. (2013, background): “FGF23 is a hormone that regulates vitamin D metabolism by down-regulating the vitamin Dsynthesizing enzyme CYP27B1 and up-regulating the vitamin Dcatabolizing enzyme CYP24A1 in kidney (Shimada et al., 2004).”