Molecular identification of a renal urate–anion exchanger that regulates blood urate levels
By A. Enomoto, Hiroaki Kimura, A. Chairoungdua, Y. Shigeta, P. Jutabha, S. Cha, M. Hosoyamada, M. Takeda, T. Sekine, T. Igarashi and 9 more. Nature, 2002
1,473 citations recorded by the source corpus.
Subfields: Molecular Biology, Nephrology, Pathology and Forensic Medicine
View Paper: https://www.semanticscholar.org/paper/57c86fd44b8c8e0c5c48aa31d34ceb58f84f97a8
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Molecular Biology
- C. Klaassen
- Lauren M. Aleksunes
- M. Roth
- A. Obaidat
- Serena Sanna
- Dale R. Nyholt
- B. Hagenbuch
- Yurii S. Aulchenko
In Nephrology
Citations in the corpus
- Pathogenesis of Gout (2005, background): “The authors searched the human genome database for novel gene sequences within the organic anion transporter (OAT) gene family and identified URAT1 (SLC22A12) (see Glossary), a novel transporter expressed at the apical brush border of the proximal nephron (63).”
- Xenobiotic, Bile Acid, and Cholesterol Transporters: Function and Regulation (2010, background): “Rodent Oat2 protein is expressed on the apical membrane of S3 proximal tubules (Table 4) (Kojima et al., 2002; Ljubojević et al., 2007), whereas human OAT2 protein is basolateral (Enomoto et al., 2002b).”
- Meta-Analysis of 28,141 Individuals Identifies Common Variants within Five New Loci That Influence Uric Acid Concentrations (2009, background): “SLC22A12 encodes the extensively studied URAT1, a member of the organic anion transporter (OAT) family [25].”
- OATPs, OATs and OCTs: the organic anion and cation transporters of the SLCO and SLC22A gene superfamilies (2012, methodology): “Using immunohistochemistry, URAT1 protein has been localized to the apical membrane of renal proximal tubules (Enomoto et al., 2002a).”
- Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout (2009, background): “Enomoto A, Endou H (2005) Roles of organic anion transporters (OATs) and a urate transporter (URAT1) in the pathophysiology of human disease.”