Interferon-gamma: an overview of signals, mechanisms and functions.

By Kate Schroder, P. Hertzog, Timothy Ravasi, David A. Hume. Journal of Leukocyte Biology, 2004

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Acellular pertussis vaccines protect against disease but fail to prevent infection and transmission in a nonhuman primate model (2013, background): “This likely explains the low IFN-γ secretion observed in all groups because antigen-presenting cells increase IFN-γ secretion by antigen-specific CD4+ T cells through a positive feedback loop (48).”
Anti-PD-1/PD-L1 therapy of human cancer: past, present, and future. (2015, unknown): “It was widely thought that IFN-γ typically promotes, rather than suppresses, T cell responses by stimulating antigen processing and presentation machinery (20, 21); therefore, the role of IFN-γ in downregulating immune responses in the tumor microenvironment via induction of PD-L1 was not well accep”
The Role of the Transcription Factor CREB in Immune Function (2010, background): “In addition, IFN-g inhibits IL-10 production and consequently blocks the immune inhibitory actions of IL-10, resulting in an enhancement of macrophage activation and immune responses (43).”
IL-12 p40 monomer is different from other IL-12 family members to selectively inhibit IL-12Rβ1 internalization and suppress EAE (2020, background): “These tyrosine phosphorylations are responsible for the formation of the STAT4/STAT4 homodimer and STAT3/ STAT4 heterodimers, which then translocate to the nucleus and bind to the IFNγ promoter for the transcription of the IFNγ gene (37).”