CD8+ T Cells Mediate Viral Clearance and Disease Pathogenesis during Acute Hepatitis B Virus Infection

By R. Thimme, S. Wieland, Carola Steiger, J. Ghrayeb, K. Reimann, R. Purcell, F. Chisari. Journal of Virology, 2003

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Human effector and memory CD8+ T cell responses to smallpox and yellow fever vaccines. (2008, background): “In contrast, T and B cell responses to chronic infections (such as HIV, HBV, and HCV) can take much longer to develop after infection (Forns et al., 2000; Sakai et al., 2007; Thimme et al., 2002; Thimme et al., 2003 ).”
Immunobiology and pathogenesis of viral hepatitis. (2006, background): “First, the beginning of liver injury coincides with the entry of virusspecific CD8+ T cells into the liver of chimpanzees infected by HBV or HCV (8, 76–78) (see also Figure 3), and depletion of these cells (but not of CD4+ cells) at the peak of viremia delays the onset of biochemical, histological, ”
Memory CD8+ T Cells Are Required for Protection from Persistent Hepatitis C Virus Infection (2003, methodology): “6 mo after clearance of the second infection, three doses of the anti-CD8 antibody cM-T807 (25, 26) were administered intravenously 14, 11, and 7 d before a third HCV challenge with 100 CID of HCV-1/ 910.”