Faculty Opinions recommendation of Intrinsic protein disorder and interaction promiscuity are widely associated with dosage sensitivity.

By Hunter B. Fraser. 2009

371 citations recorded by the source corpus.

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Motif switches: decision-making in cell regulation. (2012, positive): “As a result, to abrogate off-target effects, gene dosage of motif-containing proteins must be carefully controlled to ensure appropriate protein localisation and stoichiometry [4 ,18–20].”
Molecular chaperones in protein folding and proteostasis (2011, neutral): “Such proteins probably require assistance to avoid aberrant interactions and aggregation, particularly when their concentration is increased and they are not in complexes with partner molecule”
A Directed Protein Interaction Network for Investigating Intracellular Signal Transduction (2011, neutral): “Although in many cases, overproduction of proteins causes phenotypic effects that are different from those of gene knockdown studies, there is no obvious reason why the overall success rate between unbiased under-and overproduction screens should differ ( 56 ).”