Neurocognitive deficits and functional outcome in schizophrenia: are we measuring the "right stuff"?

By Michael F. Green, R. Kern, David L. Braff, J. Mintz. Schizophrenia bulletin, 2000

3,101 citations recorded by the source corpus.

Subfields: Cognitive Neuroscience, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/56831e35e86b423c8f8e6f77ad8cf128e18e1001

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cognitive Neuroscience

1. Michael F. Green
2. J. Cohen
3. Deanna M. Barch
4. R. Heaton
5. R. Kern
6. R. Keefe
7. Dara S. Manoach
8. D. Penn

In Psychiatry and Mental health

1. Michael F. Green
2. R. Keefe
3. R. Heaton
4. R. Kern
5. D. Penn
6. Philip D. Harvey
7. Dara S. Manoach
8. J. Cohen

Citations in the corpus

• Longitudinal studies of cognition and functional outcome in schizophrenia: implications for MATRICS. (2004, methodology): “The cross-sectional relationships between cognition and functional outcome have been well established in previous reviews (Green, 1996; Green et al., 2000), and the demonstration of these”
• A meta-analysis of neuropsychological change to clozapine, olanzapine, quetiapine, and risperidone in schizophrenia. (2005, neutral): “Cognitive impairment in schizophrenia relates directly to socio-vocational functioning (Green, 1996; Green et al., 2000), and exerts a greater influence on functional outcome than the presence or severity of the positive or negative symptoms of schizophrenia (Velligan et al., 2000).”
• The functional significance of social cognition in schizophrenia: a review. (2006, background): “variance in functional outcome is unaccounted for by traditional neurocognitive measures, spurring researchers to continue searching for other contributing factors.(11) More recently, social cognition has been identified as a likely contributor to functional outcome.”
• Cognitive deficits and functional outcome in schizophrenia (2006, background): “A number of studies since the early 1990s have found that cognitive deficits are the best predictor of functional status across a number of outcome domains and patient characteristics (see Green 1996 and Green et al 2000 for reviews).”
• Prefrontal cortex dysfunction during working memory performance in schizophrenia: reconciling discrepant findings. (2003, background): “Perhaps it is on this basis that WM deficits are consistently associated with poor functional outcome (Green et al., 2000).”
• Approaching a consensus cognitive battery for clinical trials in schizophrenia: the NIMH-MATRICS conference to select cognitive domains and test criteria. (2004, methodology): “These relationships for individual cognitive domains are usually moderate in strength, although relationships with large effects are possible (e.g., 20%-50% of the variance in outcome explained), especially when multiple cognitive domains are considered (Green et al 2000).”
• The Neuropsychological Educational Approach to Cognitive Remediation (NEAR) Model: Practice Principles and Outcome Studies (2008, background): “Cognitive impairment in psychiatric disorders has also been shown to negatively impact multiple aspects of daily functioning such as treatment response, employment status, social relationships, living status, and community functioning (Green, 1996 ; Green, Kern, Braff, & Mintz, 2000 ; Revheim & Me”