The estrogen-related receptor alpha (ERRalpha) functions in PPARgamma coactivator 1alpha (PGC-1alpha)-induced mitochondrial biogenesis.

By Sylvia N. Schreiber, R. Emter, M. Hock, Darko Knutti, Jessica Cardenas, Michael Podvinec, E. Oakeley, A. Kralli. Proceedings of the National Academy of Sciences of the United States of America, 2004

614 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/5675ce231b604eb216ee30120ce60442c36a1123

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Citations in the corpus

Regulation of energy metabolism by long-chain fatty acids. (2014, background): “ERRa induces genes for oxidative phosphorylation and ATP synthesis [158], and is also involved with mitochondrial biogenesis [159].”
Metabolic control through the PGC-1 family of transcription coactivators. (2005, background): “…this includes NRF-1 and NRF-2 (Wu et al., 1999) and the nuclear hormone receptors, such as PPARα (Vega et al., 2000), PPARδ (Wang et al., 2003), ERRα (Huss et al., 2002; Huss et al., 2004; Kamei et al., 2003; Mootha et al., 2004; Schreiber et al., 2004), and TR (Zhang et al., 2004b) (Table 1).”
Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network. (2006, background): “ERRa is one of the key transcriptional regulators for inducing oxidative gene expression and driving mitochondrial energy utilization (Luo et al., 2003; Schreiber et al., 2004; Willy et al., 2004).”
PGC1α Expression Defines a Subset of Human Melanoma Tumors with Increased Mitochondrial Capacity and Resistance to Oxidative Stress (2013, neutral): “In this regard, although small molecules targeting PGC1a do not currently exist, inhibitors of estrogen-related receptors (ERRs), key PGC1 transcription factor partners (Mootha et al., 2004; Chang et al., 2011; Schreiber et al., 2004; Eichner andGiguère, 2011;Wende et al., 2005), could potentially b”
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. (2006, background): “The estrogen-related receptor a (ERRa), which mediates many of the downstream effects of activated PGC-1a on mitochondrial function and is itself a target of PGC-1a (Huss et al., 2002; Schreiber et al., 2003; Schreiber et al., 2004; Tcherepanova et al., 2000), was markedly increased by RSV, as was t”
Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC‐1α (2007, background): “In addition, interaction of PGC-1a with PPARa and ERRa transcription factors potently induces fatty acid oxidation genes such as MCAD and CPT-1b (Vega et al, 2000; Huss et al, 2002; Mootha et al, 2004; Schreiber et al, 2004).”
Sirtuin 3, a New Target of PGC-1α, Plays an Important Role in the Suppression of ROS and Mitochondrial Biogenesis (2010, methodology): “Mitochondrial DNA (mtDNA) copy number was determined as a marker for mitochondrial density using quantitative RT-PCR as previously reported [46,47].”
Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway (2013, background): “, 2003) and a very important interactor with PGC-1a (Laganière et al., 2004; Mootha et al., 2004; Schreiber et al., 2004).”